How should the second dose of TXA be administered?

The correct method for administering the second dose of tranexamic acid (TXA) is to dilute 1g in 100ml and administer it over 8 hours. This approach is based on the pharmacokinetics and safety profile of TXA. Administering the drug slowly over a longer duration helps to reduce potential side effects, such as thromboembolic complications, while ensuring that the medication remains effective in preventing excessive bleeding.

TXA is often used in trauma settings and surgical procedures to help control bleeding. The slow infusion rate allows for better tolerance, minimizes the risk of rapid infusion reactions, and ensures that therapeutic levels of TXA are maintained in the plasma over an extended period, which is crucial for its efficacy.

Other options may suggest different volumes or rates of administration that do not align with current clinical guidelines concerning TXA dosing in a secondary administration scenario. For instance, administering a larger concentration over a short period might increase the risk of adverse effects or inconsistent therapeutic outcomes.